Kappa saphir deconvolution
7 8 In metastatic melanoma, ICIs were approved as an effective therapy option. 6 Among these, immune checkpoint inhibitors (ICI) modulating the anticancer immune response developed toward a promising treatment in tumors of various cancer entities. However, overall survival (OS) significantly improved due to novel therapy options. 4 5 The presence of distant metastases defines stage IV and thus advanced melanoma 4 with patients facing a considerably poorer prognosis than in earlier melanoma stages. 1–3 Prognosis and treatment implications highly depend on the melanoma stage classified by the criteria of the American Joint Committee on Cancer (AJCC). Malignant melanoma accounts for one of the most frequent cancer types and shows a rising incidence over the past years. Senckenberg Institute of Neurooncology, University Hospital, Frankfurt am Main, Germany 12 Department of Dermatology, University Hospital Würzburg, Würzburg, Germany.11 School of Biosciences, University of Kent, Kent, UK.10 Institute of Pathology, Ludwig Maximilians University Hospital Munich, Munich, Germany.9 Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.8 Department of Radiology, University Hospital, Frankfurt am Main, Germany.7 Department of Dermatology, University Hospital, Frankfurt am Main, Germany.
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6 Graduate School of Computer Science, Saarland Informatics Campus, Saabrücken, Germany.5 Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.4 Department of Genetics, University of Saarland, Saarbrücken, Germany.3 Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.2 German Cancer Consortium (DKTK) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.1 Neurological Institute (Edinger Institute), University Hospital, Frankfurt am Main, Germany.